Tag: chemical biology

How a Small, Organic Molecule Reigns in the Immune System

A Chinese research group has employed a chemical proteomic strategy to determine the mechanism of action of the anti-inflammatory molecule itaconate. Itaconate non-enzymatically modifies cellular proteins in order to modulate their activity, leading to a reduction in the activation of immune cells, which could pave the way to an autoimmune therapy.

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Scanning for Skin Cancer

The idea that a full body scan can give comprehensive medical prognosis may be closer than we realize. Scanning mass spectrometry has been used to differentiate between healthy and cancerous skin cells. We can literally scan a person for skin cancer!

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Destroying Rogue Kinases with Degraders

Aberrant enzyme activity drives many types of cancer and other human diseases. Traditional drugs targeting such enzymes face a variety of challenges. Here, researchers use a new small molecule “degrader” to destroy an enzyme involved in cancer.

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