Category: Biological

New Insights on The Elusive Protein Sulfinylation

Proteins bear a staggering collection of small chemical modifications that have large effects on their function. This research provides an elegant method to study cysteine sulfinylation, a chemical mark that has proven to be pretty elusive.

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‘Optical Tweezers’ give new insights to cancer drugs

By using a technique that allows researchers to study single molecules, scientists have gained new knowledge about how a common anti-cancer drug interacts with DNA. These findings can help explain the properties of the drug and help scientists discover novel r anti-cancer treatments with improved effectiveness.

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Using chemical probes to identify bacterial virulence factors

It seems like a silly question: how can we study the function of proteins with unknown functions? The answer: with activity-based chemical probes. In this article, researchers identified several previously unexplored enzymes that may play a role in serious bacterial infections.

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Painting a Fuller Picture in Medicinal Chemistry

Title: Synergistic effects of stereochemistry and appendages on the performance diversity of a collection of synthetic compounds Authors: Stu Schreiber et al. Journal: Journal of the American Chemical Society https://pubs.acs.org/doi/10.1021/jacs.8b07319 Year: 2018 The ability to rapidly evaluate what a chemical compound does to a cell, and…

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Scanning for Skin Cancer

The idea that a full body scan can give comprehensive medical prognosis may be closer than we realize. Scanning mass spectrometry has been used to differentiate between healthy and cancerous skin cells. We can literally scan a person for skin cancer!

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Destroying Rogue Kinases with Degraders

Aberrant enzyme activity drives many types of cancer and other human diseases. Traditional drugs targeting such enzymes face a variety of challenges. Here, researchers use a new small molecule “degrader” to destroy an enzyme involved in cancer.

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New Findings on Viral Inhibition

Successful resistance to a viral infection requires the host to deploy incredibly intricate biological tactics that somehow selectively inhibit key processes in the viral lifecycle. In this paper, researchers delve deeper into the molecular mechanisms of one of such resistance mechanisms!

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Can Chemists Cure the Common Cold?

Although getting the common cold is not a nice experience, it is only a relatively minor misfortune for most people. But the consqeuences of a cold can be severe. This paper describes a significant step towards a cure!

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Discovering More Structural Diversity in Bacterial Natural Products

Microorganisms are particularly remarkable at churning out structurally challenging small molecules with interesting biological functions. In this work, an unprecedented chemical transformation in one such natural products is discovered and characterized.

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Fluorogenic RNA Molecules Expand the Imaging Toolbox

Nucleic acids are incredibly versatile molecules that can perform functions way beyond their canonical roles in biology. Here, RNA sequences are “evolved” to bind and enhance the fluorescence of a small-molecule dye, welcoming the idea of RNA for robust fluorescence imaging!

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