Distinguishing sulfation from phosphorylation
REPLACING CARBON WITH SILICON
Ibuprofen is a widely used pain killers but it isn’t administered intravenously. To make it so, scientists have modified ibuprofen slightly to alter its properties.
MicroRNAs: A New Assay Searches for Targets
If your DNA is a cookbook of “recipes” your cells could make, microRNAs help decide what’s for dinner.
Prioritizing study of novel proteins
How scientists figure out what enzymes to study
Targeting a myosin motor to treat malaria
Title: Peptide Probes for Plasmodium falciparum MyoA Tail Interacting Protein (MTIP): Exploring the Druggability of the Malaria Parasite Motor Complex Authors: Charlie N. Saunders, Ernesto Cota, Jake Baum, and Edward W. Tate Journal: ACS Chemical Biology Year: 2020 Malaria is one of the world’s oldest known…
Looking for Viruses in Wild Bats
Cataloguing viruses in bats and other animals may help predict or trace viral transmission to humans in the future.
Chemical brushes in the fight against bacterial infection
Researchers develop a new two-layer coating for medical devices that dramatically reduces the chance of infection.
More than SPF: Some Common Sunscreen Ingredients to Avoid
Buying sunscreen? Take a look at the ingredients list first.
Polishing a Drug Lead: A Replacement for Opioids Reaches Clinical Trials
Many molecules can decrease enzymatic breakdown of our body’s natural painkillers…but which one is fit to be the best new drug?
A Bright New Method to Survey RNA-Small Molecule Interactions
With a growing interest in the field of RNA-targeted therapeutics, robust platforms to study RNA small-molecule interactions are needed. Read about the latest endeavor here!
Pathogenic E. coli Can Survive Stomach Acid…For Now
Infected cattle can transmit E. coli to humans through contaminated ground beef, but scientists are looking for a solution.
Masked Entry – Increasing cell permeability of large molecules
Developing a drug that is able to enter the cell and interact with its target is no mean feat, especially for large molecules. Read about how this group ‘masked’ large molecules to improve their cell permeability.
The Smell of Rain Has a Biological Function
The earthy smell of soil originates from the bacteria that live there. But why do they produce this particular scent?
DNA-based Nanocarriers to Improve the Preciseness of Drug Delivery
Tired of consuming 5 different medications a day? Read how the researchers are developing new ways to load different drugs in a single delivery system.
Unveiling cryptic compounds
How do you get microbes to produce cryptic compounds?
Biochemical Circuits: Modular Systems for Disease Detection
Instead of the wires, batteries, and light bulbs used in electric circuits, biochemical circuits use DNA and enzymes to get the job done.
Combating Viral Infection with Shape-Matching
Researchers developed a new way of tackling viral infection by designing nanostructures similar in shape to the virus particle.
Using Deep Learning to Expedite Drug Discovery
Let’s find out how researchers are using ‘artificial intelligence’ as a tool to the advancement of drug discovery.
Life in the Hot Springs: Bacterial Tricks for Thermal Stability
When cooking an egg, heat denatures proteins in the egg. How does a thermophilic bacteria prevent its proteins from denaturing too?
Release the molecule! Photolabile protecting groups
How do you design a “cage” for a molecule? And how do you release it again, selectively? Find out about a rationally designed red-light labile protecting group.
A Closer Look At The Walls of The Toughest Microbes
Mycobacteria are tough, pathogenic microbes that shield themselves with a hardy envelope known as the mycomembrane. Little is still known about the proteins that build or interact with this envelope, but these researchers are up to the challenge.
Visualising Chemistry
Appreciating the 3D structure of the tiny chemical compounds we work with can be really difficult – but what if you could project the structure onto your living room floor?
Want fluffy whole wheat bread? Use smaller flour particles
Chemists take a gander at how to make more appealing whole wheat loaves. For your COVID-19 baking needs and beyond!
Better Antibiotics: Active in the Body, Degraded in the Environment
Antibiotics are lifesaving, but current practices don’t keep them from accumulating in the environment where they can damage nature and human health. A new antibiotic design aims to solve this problem.
Expanding the Chemical Toolkit to Study Immune Cells
Their highly specialized roles of immune cells also mean they have molecular machineries that are a bit different from those in other cells, Find out here how researchers are using chemistry to advance our knowledge of one of such components, the immunoproteasome.