A Chinese research group has employed a chemical proteomic strategy to determine the mechanism of action of the anti-inflammatory molecule itaconate. Itaconate non-enzymatically modifies cellular proteins in order to modulate their activity, leading to a reduction in the activation of immune cells, which could pave the way to an autoimmune therapy.
Tag: bioorthogonal chemistry
Flavins photoactivation of prodrugs: let’s shine a light
How can flavin and flavoprotein help with cancer therapy? A very nice example of biorthogonal chemistry and its potential.