In their quest to replicate a biological cell, this group of researchers have successfully engineered a system complete with a ‘nuclear’ and a ‘cytoplasmic’ compartment! Moreover, it allows macromolecules to shuttle between the compartments, replicating a key biological functionality.
Using DNA molecules to build cool structures for novel drugs.
Title: A Plastic Biosynthetic Pathway for the Production of Structurally Distinct Microbial Sunscreens Authors: Sıla Arsın, Endrews Delbaje, Jouni Jokela, Matti Wahlsten, Zoë M. Farrar, Perttu Permi, and David Fewer Publication: Chemical Biology Year: 2023 Sunscreen protects your skin from harmful ultraviolet (UV) rays through two…
The evolution of tools to gain insights into the genome didn’t quite reach its peak with only the development of CRISPR-Cas9! The tools currently have some drawbacks including limited resources to do more high-throughput studies. Read on to know the newer developments in this field!
Fungus, as it turns out, can be beneficial, and scientists have found that fungus in the gut could improve cognition and so, might help as a treatment option for Alzheimer’s disease.
Title: Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 ImmunostainingAuthors: Jenny Jin, Kenji Schorpp, Daniel Samaga, Kristian Unger, Kamyar Hadian, and Brent R. StockwellYear: 2022Journal: ACS Chemical BiologyDOI: https://doi.org/10.1021/acschembio.1c00953 Featured image by Alex Ritter, Jennifer Lippincott Schwartz and Gillian Griffiths, National Institutes of…
We will continue coming across new viral proteins and viruses, so it doesn’t hurt to be prepared for those. The work of White et al helps in giving a starting point for medicines against the Influenza viruses.
Ibuprofen is a widely used pain killers but it isn’t administered intravenously. To make it so, scientists have modified ibuprofen slightly to alter its properties.
In diabetics, insulin production is reduced as a protease inactivates GLP1 responsible for insulin production. Administration of GLP1 could help, but it needs to be altered to sneak past the protease.
Computation has a way of finding its use in every field, and drug discovery isn’t exempt from it, especially when we are time-bound.