Tag: conjugation

How do you stick hydrophilic and hydrophobic molecules to each other?

We know that complementary functional groups are needed for strong intermolecular interactions, and that thermodynamics favours hydrophilic and hydrophobic groups each keeping themselves to themselves. So, problems can arise when trying to react very hydrophilic and very hydrophobic molecules together. This group of scientists has devised a way around the problem using a technique called solid-phase synthesis.