Monitoring Vital Signs with Temporary Tattoos

Skin-conforming, ultra-thin wearable medical sensors could make going to the doctor less invasive than ever before. This newly developed, “tattooable” sensor uses a newly developed material to create one of the thinnest yet.

A virus being attacked by host antibodies

Mapping the Targets of Antibodies against SARS-CoV-2

The worldwide death toll from the pandemic disease COVID-19 has now surpassed half a million people, sparking global vaccine development efforts. One of the most important elements in the immune system’s response to a vaccine is the antibody response, but antibodies to different parts of the invader can have different effects. In order to better understand which parts of SARS-CoV-2 are targeted by antibodies from the human immune system, Hongye Wang and colleagues developed a SARS-CoV-2 peptide array. By observing which peptides were targeted by antibodies from patients with COVID-19, the authors were able to profile which of these regions were responsible for raising antibodies. Their technology will also be useful in future vaccine development efforts.

3D printed blood vessels allow easy monitoring and experimentation

Paper: ECM-based microchannel for culturing in vitro vascular tissues with simultaneous perfusion and stretch Journal: Lab on a Chip Authors: Azusa Shimizu, Wei Huang Goh, Shun Itai, Michinao Hashimoto, Shigenori Miurad and Hiroaki Onoe Year: 2020 Featured Image: Jesus Leonardo Rondon Tapia–Creative Commons License Inflammation or…

Immune cells play important roles in COVID-19

A Solution Worse than the Problem: Using Chemistry to Understand the Runaway Immune Reaction in COVID-19

The coronavirus pandemic caused by the virus SARS-CoV-2 has now caused over 100,000 deaths in the United States alone. However, only a small fraction of people infected develop severe illness leading to death. Why do some people barely display any symptoms, while others progress to complete respiratory failure? Here, researchers at Shanghai Children’s Hospital used chemical proteomic technology to identify protein-protein interactions between SARS-CoV-2 and human proteins and use these data to better understand how the virus interacts with the immune system, leading to a runaway reaction in some patients. They also correlate levels of important immune proteins IL-6 and IL-8 to COVID-19 severity in patient samples, in agreement with their chemical proteomic data.