Fluorogenic RNA Molecules Expand the Imaging Toolbox

Nucleic acids are incredibly versatile molecules that can perform functions way beyond their canonical roles in biology. Here, RNA sequences are “evolved” to bind and enhance the fluorescence of a small-molecule dye, welcoming the idea of RNA for robust fluorescence imaging!

Shining Light on Aldehyde Synthesis

Photoredox catalysis is at it again! This time it is used to synthesize polysubstituted aldehydes – highly useful building blocks – from readily available styrenes and vinyl ethers.

How do you stick hydrophilic and hydrophobic molecules to each other?

We know that complementary functional groups are needed for strong intermolecular interactions, and that thermodynamics favours hydrophilic and hydrophobic groups each keeping themselves to themselves. So, problems can arise when trying to react very hydrophilic and very hydrophobic molecules together. This group of scientists has devised a way around the problem using a technique called solid-phase synthesis.