Month: February 2011

Attaching small molecules to the Staphylococcus aureus cell wall

A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-native Small Molecules James W. Nelson, Alexander G. Chamessian, Patrick J. McEnaney, Ryan P. Murelli, Barbara I. Kazmiercak, David A. Spiegel* Departments of Chemistry and Medicine, Yale University, New Haven, CT ACS Chem. Bio. 2010,…

A synthesis of strychnine by a longest linear sequence of six steps

A synthesis of strychnine by a longest linear sequence of six steps David B. C. Martin and Christopher D. Vanderwal* Department of Chemistry, University of California, Irvine Chemical Science, Advanced Article Strychnine, a crystalline alkaloid known to most as a powerful toxin used in pesticides, has…

Distinguishing Between Pathways for Transmetalation in Suzuki-Miyaura Reactions

Distinguishing Between Pathways for Transmetalation in Suzuki-Miyaura Reactions Brad P. Carrow and John F. Hartwig* J. Am. Chem. Soc. 2011, 133, 2116. The Suzuki-Miyaura cross-coupling reaction (Fig. 1) is definitely one of the most important reactions in synthetic chemistry, especially in industrial and medical settings.   So…

Activating efficient phosphorescence from purely organic materials by crystal design

Journal: Nature Chemistry Authors: Onas Bolton, Kangwon Lee, Hyong-Jun Kim, Kevin Y. Lin, and Jinsang Kim Affiliation: University of Michigan, Ann Arbor Phosphorescent materials, those which emit light long after excitation, have found increasing use in organic electronics as well as chemical and biological sensing. Perhaps…

Trinuclear Copper Complex

Title: Trinucleating Copper: Synthesis and Magnetostructural Characterization of Complexes Supported by a Hexapyridyl 1,3,5-Triarylbenzene Ligand Authors: Emily Y. Tsui, Dr. Michael W. Day, Prof. Theodor Agapie Journal: Angewandte Chemie International Edition Affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology Cartoon of the Trinuclear Copper…

Cu(II) coordination in Proteins

Coordination Features and Affinity of the Cu2+ site in the alpha-Synuclein Protein of Parkinson’s Disease Dudzik, C.G.; Walter, E.D. and Millhauser, G.L. Biochemistry ASAP Alpha-synuclein proteins, concentrated in neurons in the human body, are composed of mostly hydrophobic residues. The hydrophobicity of the protein results in…

MRI agent for imaging myelin

Title: A Myelin-Specific Contrast Agent for Magnetic Resonance Imaging of Myelination Journal: Journal of the American Chemical Society Authors: Luca Frullano*, Changning Wang*, Robert H. Miller**, and Yanming Wang* Affiliation: *Division of Radiopharmaceutical Science, Case Center for Imaging Research, Department of Radiology, and **Department of Neuroscience,…

DNA film with light switching capabilities

Title: Preparation of [Ru(bpy)2(dppz)]2+-Intercalated DNA Cast Films Using a Self-Standing Method and Its Luminescence Tuning by Cu2+ Ions and EDTA Journal: Inorganic Chemistry Authors: Miojing Chen,* Hong Li,* Jiangyan Shao,* Yan Huang,* and Zheng Xu** Affiliation: *Key Lab of Technology on Electrochemical Energy Storage and Power…

Anti-cancer nanomaterials

Title:  Photothermally Enhanced Drug Delivery by Ultrasmall Multifunctional FeCo Journal:  ACS Nano Authors:  Sarah P. Sherlock, Scott M. Tabakman, Liming Xie, and Hongjie Dai Affiliation:  Stanford University, Department of Chemistry Nanomaterials have a wide variety of uses and we have just begun to discover their capabilities.  They…