Attaching small molecules to the Staphylococcus aureus cell wall

A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-native Small Molecules James W. Nelson, Alexander G. Chamessian, Patrick J. McEnaney, Ryan P. Murelli, Barbara I. Kazmiercak, David A. Spiegel* Departments of Chemistry and Medicine, Yale University, New Haven, CT ACS Chem. Bio. 2010, 5, 1147-55. Over the past few decades, many hospital … Continue reading


A synthesis of strychnine by a longest linear sequence of six steps

A synthesis of strychnine by a longest linear sequence of six steps David B. C. Martin and Christopher D. Vanderwal* Department of Chemistry, University of California, Irvine Chemical Science, Advanced Article Strychnine, a crystalline alkaloid known to most as a powerful toxin used in pesticides, has long been a target of interest for synthetic organic … Continue reading


Distinguishing Between Pathways for Transmetalation in Suzuki-Miyaura Reactions

Distinguishing Between Pathways for Transmetalation in Suzuki-Miyaura Reactions Brad P. Carrow and John F. Hartwig* J. Am. Chem. Soc. 2011, 133, 2116. The Suzuki-Miyaura cross-coupling reaction (Fig. 1) is definitely one of the most important reactions in synthetic chemistry, especially in industrial and medical settings.   So one would think that the mechanism of this classic … Continue reading


Activating efficient phosphorescence from purely organic materials by crystal design

Journal: Nature Chemistry Authors: Onas Bolton, Kangwon Lee, Hyong-Jun Kim, Kevin Y. Lin, and Jinsang Kim Affiliation: University of Michigan, Ann Arbor Phosphorescent materials, those which emit light long after excitation, have found increasing use in organic electronics as well as chemical and biological sensing. Perhaps the most well-known phosphors are the greenish glow-in-the-dark materials … Continue reading


Trinuclear Copper Complex

Title: Trinucleating Copper: Synthesis and Magnetostructural Characterization of Complexes Supported by a Hexapyridyl 1,3,5-Triarylbenzene Ligand Authors: Emily Y. Tsui, Dr. Michael W. Day, Prof. Theodor Agapie Journal: Angewandte Chemie International Edition Affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology Cartoon of the Trinuclear Copper Complex: The nitrogen donors are 2-pyridyl moities.  Note: Variable … Continue reading

Biological / Inorganic

Cu(II) coordination in Proteins

Coordination Features and Affinity of the Cu2+ site in the alpha-Synuclein Protein of Parkinson’s Disease Dudzik, C.G.; Walter, E.D. and Millhauser, G.L. Biochemistry ASAP Alpha-synuclein proteins, concentrated in neurons in the human body, are composed of mostly hydrophobic residues. The hydrophobicity of the protein results in frequent aggregation or ‘clumping together’ of multiple alpha-syn proteins … Continue reading


MRI agent for imaging myelin

Title: A Myelin-Specific Contrast Agent for Magnetic Resonance Imaging of Myelination Journal: Journal of the American Chemical Society Authors: Luca Frullano*, Changning Wang*, Robert H. Miller**, and Yanming Wang* Affiliation: *Division of Radiopharmaceutical Science, Case Center for Imaging Research, Department of Radiology, and **Department of Neuroscience, Case Western Reserve University Artistic rendering of the applications … Continue reading