In organic chemistry, once your reaction is over you generally “work-up” the mixture. But what happens if the work-up changes the outcome?
Author: Aimee Horsfall
I have just submitted my PhD thesis at the University of Adelaide (Australia), and am now working as a Research Fellow at the University of Auckland (New Zealand). As a peptide chemist I synthesise peptides with defined secondary structure to study protein-protein interactions and develop therapeutic inhibitors of biologically important interactions. I have a passion for effective science communication, find me on Twitter @aimeehorsfall or linkedin/in/aimeehorsfall
Another side (product) of synthesising antibiotic, daptomycin
Finding new antibiotics is difficult. Synthesising those new antibiotics can be just as hard, and sometimes is takes a long time to find a good approach. And sometimes the most important step in synthesis optimisation is characterising your side-products.
Masked Entry – Increasing cell permeability of large molecules
Developing a drug that is able to enter the cell and interact with its target is no mean feat, especially for large molecules. Read about how this group ‘masked’ large molecules to improve their cell permeability.
#BlackInChem: Science & Equity go hand in hand – Ayanna Jones
Ayanna Jones, a PhD student and passionate advocate for representation in science, shares her story and advice on making chemistry more inclusive
Release the molecule! Photolabile protecting groups
How do you design a “cage” for a molecule? And how do you release it again, selectively? Find out about a rationally designed red-light labile protecting group.
Visualising Chemistry
Appreciating the 3D structure of the tiny chemical compounds we work with can be really difficult – but what if you could project the structure onto your living room floor?
Chemistry & COVID-19
The COVID-19 pandemic is consuming our news feed at the moment – while you’re self-isolating read about some of the great science research going on to combat our newest virus.
Seeing the Invisible
Ever wondered how scientists know what is going on inside a cell, or how you could design a chemical probe to tell you more? There’s a lot of things to consider, find out more here.
Peering inside the cell
Everyday your cells are working overtime to keep you functioning. Learn how these researchers developed a new technique to peer through the crowded cell and study one individual protein.