Author: Emilia

New Insights on The Elusive Protein Sulfinylation

Proteins bear a staggering collection of small chemical modifications that have large effects on their function. This research provides an elegant method to study cysteine sulfinylation, a chemical mark that has proven to be pretty elusive.

1 Shares

Painting a Fuller Picture in Medicinal Chemistry

Title: Synergistic effects of stereochemistry and appendages on the performance diversity of a collection of synthetic compounds Authors: Stu Schreiber et al. Journal: Journal of the American Chemical Society https://pubs.acs.org/doi/10.1021/jacs.8b07319 Year: 2018 The ability to rapidly evaluate what a chemical compound does to a cell, and…

0 Shares

New Findings on Viral Inhibition

Successful resistance to a viral infection requires the host to deploy incredibly intricate biological tactics that somehow selectively inhibit key processes in the viral lifecycle. In this paper, researchers delve deeper into the molecular mechanisms of one of such resistance mechanisms!

5 Shares

Discovering More Structural Diversity in Bacterial Natural Products

Microorganisms are particularly remarkable at churning out structurally challenging small molecules with interesting biological functions. In this work, an unprecedented chemical transformation in one such natural products is discovered and characterized.

7 Shares

Fluorogenic RNA Molecules Expand the Imaging Toolbox

Nucleic acids are incredibly versatile molecules that can perform functions way beyond their canonical roles in biology. Here, RNA sequences are “evolved” to bind and enhance the fluorescence of a small-molecule dye, welcoming the idea of RNA for robust fluorescence imaging!

2 Shares

Shining Light on Aldehyde Synthesis

Photoredox catalysis is at it again! This time it is used to synthesize polysubstituted aldehydes – highly useful building blocks – from readily available styrenes and vinyl ethers.

6 Shares

A Radical Way to Label Proteins

Read about this new approach to selectively install fluorines into proteins using a mild radical source.

2 Shares

A New Dichlorination of Alkenes: A Radical Twist to a Long-sought Transformation

Title: Electrocatalytic Radical Dichlorination of Alkenes with Nucleophilic Chlorine Sources Authors: Niankai Fu, Gregory S. Sauer, and Song Lin Journal: Journal of the American Chemical Society http://pubs.acs.org/doi/10.1021/jacs.7b09388 Year: 2017 The unsaturated bond of an alkene is one of the most exploited functionalities inside the organic chemist’s…

1 Shares