Author: Emilia

Improving known chemistry through biocatalysis

Reductive amination is the to-go method to make diverse amines we learn in undergraduate chemistry, but it has its set of limitations. Learn how researchers are trying to address these challenges and make the reaction greener through the power of protein enzymes.


New Insights on The Elusive Protein Sulfinylation

Proteins bear a staggering collection of small chemical modifications that have large effects on their function. This research provides an elegant method to study cysteine sulfinylation, a chemical mark that has proven to be pretty elusive.


Painting a Fuller Picture in Medicinal Chemistry

Title: Synergistic effects of stereochemistry and appendages on the performance diversity of a collection of synthetic compounds Authors: Stu Schreiber et al. Journal: Journal of the American Chemical Society Year: 2018 The ability to rapidly evaluate what a chemical compound does to a cell, and…


New Findings on Viral Inhibition

Successful resistance to a viral infection requires the host to deploy incredibly intricate biological tactics that somehow selectively inhibit key processes in the viral lifecycle. In this paper, researchers delve deeper into the molecular mechanisms of one of such resistance mechanisms!


Discovering More Structural Diversity in Bacterial Natural Products

Microorganisms are particularly remarkable at churning out structurally challenging small molecules with interesting biological functions. In this work, an unprecedented chemical transformation in one such natural products is discovered and characterized.


Fluorogenic RNA Molecules Expand the Imaging Toolbox

Nucleic acids are incredibly versatile molecules that can perform functions way beyond their canonical roles in biology. Here, RNA sequences are “evolved” to bind and enhance the fluorescence of a small-molecule dye, welcoming the idea of RNA for robust fluorescence imaging!


Shining Light on Aldehyde Synthesis

Photoredox catalysis is at it again! This time it is used to synthesize polysubstituted aldehydes – highly useful building blocks – from readily available styrenes and vinyl ethers.


A Radical Way to Label Proteins

Read about this new approach to selectively install fluorines into proteins using a mild radical source.


A New Dichlorination of Alkenes: A Radical Twist to a Long-sought Transformation

Title: Electrocatalytic Radical Dichlorination of Alkenes with Nucleophilic Chlorine Sources Authors: Niankai Fu, Gregory S. Sauer, and Song Lin Journal: Journal of the American Chemical Society Year: 2017 The unsaturated bond of an alkene is one of the most exploited functionalities inside the organic chemist’s…