Author: Emilia

Painting a Fuller Picture in Medicinal Chemistry

Title: Synergistic effects of stereochemistry and appendages on the performance diversity of a collection of synthetic compounds Authors: Stu Schreiber et al. Journal: Journal of the American Chemical Society https://pubs.acs.org/doi/10.1021/jacs.8b07319 Year: 2018 The ability to rapidly evaluate what a chemical compound does to a cell, and…

New Findings on Viral Inhibition

Successful resistance to a viral infection requires the host to deploy incredibly intricate biological tactics that somehow selectively inhibit key processes in the viral lifecycle. In this paper, researchers delve deeper into the molecular mechanisms of one of such resistance mechanisms!

Fluorogenic RNA Molecules Expand the Imaging Toolbox

Nucleic acids are incredibly versatile molecules that can perform functions way beyond their canonical roles in biology. Here, RNA sequences are “evolved” to bind and enhance the fluorescence of a small-molecule dye, welcoming the idea of RNA for robust fluorescence imaging!

Shining Light on Aldehyde Synthesis

Photoredox catalysis is at it again! This time it is used to synthesize polysubstituted aldehydes – highly useful building blocks – from readily available styrenes and vinyl ethers.

A New Dichlorination of Alkenes: A Radical Twist to a Long-sought Transformation

Title: Electrocatalytic Radical Dichlorination of Alkenes with Nucleophilic Chlorine Sources Authors: Niankai Fu, Gregory S. Sauer, and Song Lin Journal: Journal of the American Chemical Society http://pubs.acs.org/doi/10.1021/jacs.7b09388 Year: 2017 The unsaturated bond of an alkene is one of the most exploited functionalities inside the organic chemist’s…