Author: Alice Herneisen

Using chemical probes to identify bacterial virulence factors

It seems like a silly question: how can we study the function of proteins with unknown functions? The answer: with activity-based chemical probes. In this article, researchers identified several previously unexplored enzymes that may play a role in serious bacterial infections.


Destroying Rogue Kinases with Degraders

Aberrant enzyme activity drives many types of cancer and other human diseases. Traditional drugs targeting such enzymes face a variety of challenges. Here, researchers use a new small molecule “degrader” to destroy an enzyme involved in cancer.