Category: Research Bites

Seeing the Invisible

Ever wondered how scientists know what is going on inside a cell, or how you could design a chemical probe to tell you more? There’s a lot of things to consider, find out more here.

Identifying the Molecular Mechanism of a Targeted Cancer Therapeutic Lead Compound

Molecules that target specific aspects of cancer biology are of great interest due to the improved efficacy and reduced side effects for patients relative to chemotherapy. Scientists have identified many compounds that can selectively kill cancer cells, but it is not yet understood how most of them work. Here, Madhusudhan and coauthors have used chemical probes and mass spectrometry to identify the targets of potential new targeted lung cancer therapies against a protein complex in the mitochondria. This complex currently has no approved targeted therapies against it, making it an exciting prospect for a whole new class of anticancer agents.