Scientists want to use nanoparticles to deliver drugs straight to where they’re needed in your body – but can the nanoparticles enter the right cells? A new model describes how to design nanoparticles that get to where they’re needed.
Category: Biological
Delicious diagnosis – real-time glucose analysis straight from your gut
Scientists from UCSD and Compultense University developed non-invasive tools to measure gastrointestinal distress, monitoring chemical markers in real-time.
Nanoparticle Made of DNA Degrades Cancerous HER2 Protein
DNA can be more than just the genetic code. Can four specially designed strands of DNA destroy cancer cells?
Smelling chemicals with an artificial nose
Nothing compares to a well-trained dog’s nose for smelling out faint odors. But a new artificial nose made with living cells may come close!
Finding Genes that Fit: Targeting DNA Bases
Changes in our DNA can cause a host of health issues. However, we can mitigatge a lot of those if we can identify and catalogue these changes, potentially developing novel treatments.
Manipulating actinomycetes for unusual antibiotics
Scientists genetically modify bacteria to overproduce uncommon antibiotics, revealing information on how bacteria regulate and modify its metabolites.
Using microbes to make natural products
Microbial systems can be a great way to make complicated products that are useful to humans. However, because the pathways to make these products involve multiple steps and can be very complex, sometimes it’s just too difficult for one species to accomplish on its own. But working as a team with another species of microbe can have its own problems. How can researchers decide which way is best?
Did life come from the depths of the ocean?
Amino acids were found in the Atlantis Massif, under the ocean floor. Is their non-biological synthesis the origin of life?
Ancient biochemistry—your four billion year old ribosome!
Four billion years ago the Earth cooled, cyanobacteria gave us our oxygen-rich atmosphere, and your ribosomes started synthesizing proteins!
New Insights on The Elusive Protein Sulfinylation
Proteins bear a staggering collection of small chemical modifications that have large effects on their function. This research provides an elegant method to study cysteine sulfinylation, a chemical mark that has proven to be pretty elusive.
How do our cells sense touch?
Learn about new discoveries into how plants and animals sense the world around them on a microscopic level!
Nanoparticles for Cancer Detection and Treatment
New nanoparticle devices can respond to ATP levels, deliver drugs, and induce their own removal from cells. Read about the structure of these nanoparticles and how they can advance cancer therapy and diagnostics!
Antibacterial Screening In Live Cells: In Search Of Life-Saving Drugs
Just as interesting as the detail of how the antibacterial molecules works can be the new methods by which they are discovered. Today’s Chembite is about the development of antibacterial agents in the fight against an infectious bacterium.
‘Optical Tweezers’ give new insights to cancer drugs
By using a technique that allows researchers to study single molecules, scientists have gained new knowledge about how a common anti-cancer drug interacts with DNA. These findings can help explain the properties of the drug and help scientists discover novel r anti-cancer treatments with improved effectiveness.
Using Machine Learning to Discover New Fluorescent Proteins
Fluorescent proteins are incredibly useful for exploring the inside of living cells. Let’s learn about a new way to find better-performing proteins using machine learning!
A surprising answer for how cells deal with a toxic – but essential – molecule
Heme is central to many processes within cells, from breaking down food to energy to transporting oxygen from the air we breathe. Bound to proteins it’s extremely useful and versatile, but by itself it is highly reactive and toxic. So how does the body prevent heme from reacting before it is used in a cell?
Using chemical probes to identify bacterial virulence factors
It seems like a silly question: how can we study the function of proteins with unknown functions? The answer: with activity-based chemical probes. In this article, researchers identified several previously unexplored enzymes that may play a role in serious bacterial infections.
Painting a Fuller Picture in Medicinal Chemistry
Title: Synergistic effects of stereochemistry and appendages on the performance diversity of a collection of synthetic compounds Authors: Stu Schreiber et al. Journal: Journal of the American Chemical Society https://pubs.acs.org/doi/10.1021/jacs.8b07319 Year: 2018 The ability to rapidly evaluate what a chemical compound does to a cell, and…
Scanning for Skin Cancer
The idea that a full body scan can give comprehensive medical prognosis may be closer than we realize. Scanning mass spectrometry has been used to differentiate between healthy and cancerous skin cells. We can literally scan a person for skin cancer!
Destroying Rogue Kinases with Degraders
Aberrant enzyme activity drives many types of cancer and other human diseases. Traditional drugs targeting such enzymes face a variety of challenges. Here, researchers use a new small molecule “degrader” to destroy an enzyme involved in cancer.
A New Duo in Catalysis: Combining Gold Nanoparticles with Enzyme Compartments
Biological catalysts and inorganic catalysts each have their own advantages and it is sometimes difficult to choose one or the other. So why not combine them into a powerful hybrid catalyst? That’s exactly what the researchers did in this recent article from ACS Catalysis.
New Findings on Viral Inhibition
Successful resistance to a viral infection requires the host to deploy incredibly intricate biological tactics that somehow selectively inhibit key processes in the viral lifecycle. In this paper, researchers delve deeper into the molecular mechanisms of one of such resistance mechanisms!
Can Chemists Cure the Common Cold?
Although getting the common cold is not a nice experience, it is only a relatively minor misfortune for most people. But the consqeuences of a cold can be severe. This paper describes a significant step towards a cure!
Photocages: Using Light to Deliver Medicine
What will medicine look like 10 years from now? Well, your doctor might be shining a light on you to help target drug delivery in your body. Read more about drug delivery using molecules called photocages inside!
Discovering More Structural Diversity in Bacterial Natural Products
Microorganisms are particularly remarkable at churning out structurally challenging small molecules with interesting biological functions. In this work, an unprecedented chemical transformation in one such natural products is discovered and characterized.